Tamibarotene is a novel selective retinoid alpha-receptor enhancer for the treatment of acute promyelocytic leukemia relapse or refractory disease. Tamibarotene is characterized by its high potency, low resistance and small side effects. However, its application is limited due to its poor solubility in water, oral administration in a common formulation, poor absorption and low bioavailability.
Zhiyuan Biotechnology recent search through the literature and found that my company's cyclodextrin and its derivatives can be combined Tamibarotene, the formation of Tamibarotene inclusion compound. Tamoxarodine clathrate has the characteristics of good water solubility and small blood vessel irritation, and is particularly suitable for preparing liquid formulation, especially for injection dosage forms. The solid preparation prepared by the method has the characteristics of quick disintegration, good dissolution and high bioavailability, which is more conducive to clinical application.
